The Asthma Control Test and its Relationship with Lung Function Parameters

The Asthma Control Test (ACT) is a validated, simple,and inexpensive instrument to assess control among patients with bronchial asthma. However, its relationship with lung function parameters is yet to be demonstrated among Nigerian asthma patients. Our study aimed at assessing asthma control using ACT scores and determining its relationship with lung function parameters among persons with asthma in a university respiratory clinic.The cross-sectional study included 65 patients with bronchial asthma who underwent routine check-ups in respiratory clinics at the Obafemi Awolowo University Teaching Hospital Complex (OAUTHC), Ile-Ife, Nigeria between October 2009 and January 2011. The ACT was administered to assess for asthma control. Lung function testing was done using the guidelines of the American Thoracic Society (ATS).The mean pre-bronchodilator FEV1 (forced expiratory volume in 1 second) was 1.97±0.87L and mean ACT score was 18.2+4.28; 24 (37%) of the study subjects had well-controlled asthma. The ACT scores were weakly correlated with percentage of predicted,FEV1(r=0.220, p=<0.078) and PEF (peak expiratoryflow), (r=0.168,p=0.18).In this study, most of the patients had poor asthma control and lung function parameters correlated poorly with ACT scores. It is important that the ACT complements other physiological measures of assessing asthma control in our environment

Assessment of Lung Function Parameters in Nigerian Males with Diabetes

Despite scarce information on the implications of diabetes for pulmonary function; existing evidence suggests that the respiratory system might also be affected by diabetes. We therefore conducted a crosssectional study of pulmonary function in male Nigerian diabetes patients using spirometric indices. Seventy-six male diabetes patients aged 27-80 years were studied at the Endocrinology and Diabetes Clinic at the Obafemi Awolowo University Teaching Hospital; Ile-Ife; Nigeria. Overall; all lung function parameters/volumes studied were significantly lower in the diabetes patients compared with predicted values p=0.000. Patients' ages correlated negatively with all spirometric indices but there was no significant relationship between lung function and fasting blood sugar; body mass index; or diabetic microvascular complications. The implications of abnormal lung function parameters for respiratory disease in diabetes are unclear. Routine tests of pulmonary function are not presently indicated in Nigerian diabetes patients

Health-related quality of life among patients with bronchial asthma in Ile-Ife, Nigeria

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A five-year review of tuberculosis mortality amongst hospitalised patients in Ile-Ife.

BACKGROUND: Death from tuberculosis (TB) is the longest recorded indicator of the TB epidemic in industrialised countries. This study aims at investigating into various factors associated with death in hospitalised patients with tuberculosis in Ile-Ife, Nigeria. METHODS: A retrospective study of all admissions into the medical wards, total number of deaths and number of cases of deaths due to TB during the period 1998-2000 was done. RESULTS: Tuberculosis represented 8% (268) of all admissions (n=3464). The overall hospital mortality during the period under review was 1030 (30%). Tuberculosis was responsible for 5% of all deaths while TB specific mortality was 18.3 percent. The highest mortality was observed among patients between the 3rd and 4th decade of life with a male to female ratio 1.3: 1. About 70% of the patients died within a week of admission. Pulmonary TB was responsible for 69% of deaths followed by tuberculous meningitis (14%), retroviral illness (24%), anaemia (60%). Delayed presentation and diagnosis were identified as factors commonly associated with death rate. CONCLUSIONS: Delayed presentation and diagnosis were commonly associated with death. There is a need for more awareness among patients and health care providers about tuberculosis.

Typhoid and paratyphoid fever: a retrospective study.

Sixty-eight proved cases of typhoid and paratyphoid fever were reviewed in a retrospective study covering 5 years (1986-1990). Patients within the age range of 10 to 39 years constituted 82.3 per cent of cases and there was equal incidence in both sexes. The mean duration of illness before presentation was 9.67 days. The major clinical features were fever (97%), abdominal tenderness (-9.4%), headache and abdominal pain (70.58%) each). Intestinal perforation was the commonest complication (27.9%) with a male preponderance (M:F-3:1). Perforation occurred after the first week of illness in 73.7 per cent of cases. Fourteen out of the nineteen patients who perforated were not on therapy at the time of perforation and they constituted 80 per cent of those cases of mortality in which perforation played a role. Surgical management of perforation gave better results than conservative management (mortality rates of 16.7% and 40% respectively). Salmonella was sensitive to Chloramphenicol in all the cases where the organism was grown. There were 10 recorded deaths (14.9%) of whom 60 per cent (i. e. 6 patients) presented after two weeks of illness.